A crossover fighting game which features characters by 20th Century Fox & Toei.
Playable Characters
| 20th Century Fox | Toei | Guests |
| Homer Simpson | Red Buster | Mario (WiiU/3DS Exclusvie) |
| Marge Simpson | Blue Buster | Luigi (WiiU/3DS Exclusvie) |
| Bart Simpson | Yellow Buster | Princess Peach (WiiU/3DS Exclusvie) |
| Lisa Simpson | Beet Buster | Yoshi (WiiU/3DS Exclusvie) |
| Peter Griffin | Stag Buster | Wario (WiiU/3DS Exclusvie) |
| Lois Griffin | Uchuu Keiji Gavan | Donkey Kong (WiiU/3DS Exclusvie) |
| Stewie Griffin | Kamen Rider Den-O | Banjo & Kazooie (Xbox360 Exclusive) |
| Cleveland Brown | Momotaros | Conker (Xbox360 Exclusive) |
| Stan Smith | Ryutaros | Sackboy (PS3/Vita Exclusive) |
| Turanga Leela | Kintaros | Sir Daniel Fortesque (PS3/Vita Exclusive) |
| Bender | Urataros | Sly Cooper (PS3/Vita Exclusive) |
| Sid the Sloth | Sailor Moon | Kratos (PS3/Vita Exclusive) |
| Rodney Copperbottom | Cure Happy | Shrek |
| Hank Hill | Cure Sunny | Princess Fiona |
| Predator | Cure March | Donkey |
| Major Dutch Schaefer | Cure Peace | Puss in Boots |
| Lt. Linn Kurosawa | Cure Beauty | Artie |
| Rasputin | San Dorva | Prince Charming |
DLC
| 20th Century Fox | Toei |
| Krusty the Clown | Spider-Man (Toei) |
| Dr. Zoidberg | Shuya Nahahara |
| Tim the Bear | Nagamine Shigeki |
| Mr. Burns (Ultimate Only) | Enter (Ultimate Only) |
| Mom (Ultimate Only) | Tuxedo Kamen (Ultimate Only) |
| Giant Chicken (Ultimate Only) | Basco ta Jolokia (Ultimate Only) |
Ultimate 20th Century Fox VS Toei
| 20th Century Fox | Toei |
| Buck | Cure Black |
| Captain Gutt | Cure White |
| Luke Skywalker | Gokai Red |
| Han Solo | Gokai Blue |
| Yoda | Gokai Green |
| Darth Vader | Gokai Yellow |
| Edward Scissorhands | Gokai Pink |
| Boba Fett | Gokai Silver |
NPC'S
| 20th Century Fox | Toei |
| Manny (Hyper Combo for Sid) | Sailor Mercury (Special Attack for Sailor Moon) |
| Diego (Special Attack for Sid) | Sailor Mars (Special Attack for Sailor Moon) |
| Phillip J. Fry (Hyper Combo for Bender) | Sailor Jupiter (Special Attack for Sailor Moon) |
| Maggie Simpson (Special Attack for Marge Simpson) | Sailor Venus (Special Attack for Sailor Moon) |
| Brian Griffin (Hyper Combo for Stewie Griffin) | Marin (Heal for Uchuu Keiji Gavan) |
| Santa's Little Helper (Special Attack for Bart Simpson) | Kamen Rider Wizard (Hyper Combo for Kamen Rider Den-O) |
| Snowball II (Special Attack for Lisa Simpson) | Sailor Chibi Moon (Special Attack for Sailor Moon) |
| Squint, Flynn, Silas, Gupta & Raz (Special Attack/Hyper Combo for Captain Gutt) | Amazoness (Hyper Combo for Spider-Man (Toei)) |
| Chewbacca (Special Attack for Han Solo) | Garia (Heal/Buff for Spider-Man (Toei)) |
| Emperor Palpatine (Hyper Combo for Darth Vader) | Shiny Luminous (Buff for Cure Black/Cure White) |
| Fender Pinwheeler (Hyper Combo for Rodney Copperbottom) | Escape (Hyper Combo/Special Attack for Enter) |
| Waylon Smithers (Special Attack/Hyper Combo/Heal for Mr. Burns) | Sally (Hyper Combo for Basco ta Jolokia) |
| Peaches (Hyper Combo for Mom) |
Other Fox/Toei characters make cameos in stages and character endings.
Final Boss
Hexxessiah, a fusion of Hexxus & Messiah.
The REAL Final Boss
THE JAPANESE VIDEO GAME ANNOUNCER!